產(chǎn)品詳情介紹
CD105，又稱為內(nèi)皮糖蛋白，是一種以二硫鍵連接的同型二聚體跨膜蛋白。CD105是TGF-β受體復(fù)合體的輔助受體，在相關(guān)信號(hào)轉(zhuǎn)導(dǎo)通路中發(fā)揮作用[1,2]。CD105在血管內(nèi)皮細(xì)胞中高度表達(dá)，是腫瘤血管生成的標(biāo)志性分子[3]。此外，CD105也在活化的單核細(xì)胞和巨噬細(xì)胞表面表達(dá)[4]。它在血管生成調(diào)節(jié)中起重要作用[5,6]。本產(chǎn)品為小鼠抗人CD105單克隆抗體，用于FC方法特異性檢測(cè)人CD105蛋白。
CD系列產(chǎn)品介紹視頻
[1] Bernabeu C, Conley BA, Vary CPH. Novel biochemical pathways of endoglin in vascular cell physiology [J]. Journal of Cellular Biochemistry. 2007, 102(6): 1375-88.
[2] Zhu Y, Sun Y, Xie L, et al. Hypoxic induction of endoglin via mitogen-activated protein kinases in mouse brain microvascular endothelial cells [J]. Stroke. 2003, 34(10): 2483-8.
[3] Fonsatti E, Sigalotti L, Arslan P, et al. Emerging role of endoglin (CD105) as a marker of angiogenesis with clinical potential in human malignancies [J]. Curr Cancer Drug Targets. 2003, 3(6): 427-32.
[4] Lastres P, Bellon T, Caba?as C, et al. Regulated expression on human macrophages of endoglin, an Arg-Gly-Asp-containing surface antigen [J]. Eur J Immunol. 1992, 22(2): 393-7.
[5] Castonguay R, Werner ED, Matthews RG, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth [J]. J Biol Chem. 2011, 286(34): 30034-46.
[6] Nolan-Stevaux O, Zhong W, Culp S, et al. Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies [J]. PLoS One. 2012, 7(12): e50920.
